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Index > Protein center > Fads2(Gene name) > Rat
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  • Fads2 (Gene name),
  • Fatty acid desaturase 2 (Protein name ),  FADS2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fads2(Fadsd6);
    Protein name:
    Fatty acid desaturase 2;
    Alternative:
    Delta(6) fatty acid desaturase(D6D;Delta(6) desaturase;Delta-6 desaturase);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    444
    Sequence:
    50:
    MGKGGNQGEG | STELQAPMPT | FRWEEIQKHN | LRTDRWLVID | RKVYNVTKWS | 
    100:
    QRHPGGHRVI | GHYSGEDATD | AFRAFHLDLD | FVGKFLKPLL | IGELAPEEPS | 
    150:
    LDRGKSSQIT | EDFRALKKTA | EDMNLFKTNH | LFFFLLLSHI | IVMESIAWFI | 
    200:
    LSYFGNGWIP | TVITAFVLAT | SQAQAGWLQH | DYGHLSVYKK | SIWNHIVHKF | 
    250:
    VIGHLKGASA | NWWNHRHFQH | HAKPNIFHKD | PDIKSLHVFV | LGEWQPLEYG | 
    300:
    KKKLKYLPYN | HQHEYFFLIG | PPLLIPMYFQ | YQIIMTMIRR | RDWVDLAWAI | 
    350:
    SYYARFFYTY | IPFYGILGAL | VFLNFIRFLE | SHWFVWVTQM | NHIVMEIDLD | 
    400:
    HYRDWFSSQL | AATCNVEQSF | FNDWFSGHLN | FQIEHHLFPT | MPRHNLHKIA | 
    444:
    PLVKSLCAKH | GIEYQEKPLL | RALLDIVSSL | KKSGELWLDA | YLHK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Fatty acid desaturase 2
    Cat.:
    E0400h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Fatty acid desaturase 2
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    E0400r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Fatty acid desaturase 2
    Cat.:
    E0400m
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    96T
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    ELISA Kit for Rat Fatty acid desaturase 2
    Cat.:
    E0400b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Rat Fatty acid desaturase 2
    Cat.:
    U0400b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Fatty acid desaturase 2
    Cat.:
    U0400r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Fatty acid desaturase 2
    Cat.:
    U0400h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Fatty acid desaturase 2
    Cat.:
    U0400m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Fatty acid desaturase 2
    Polyclonal Antibody for Rat Fatty acid desaturase 2
    Cat.:
    P0400Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Fatty acid desaturase 2
    Cat.:
    P0400Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Fatty acid desaturase 2
    Cat.:
    P0400Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Fatty acid desaturase 2
    Monoclonal Antibody for Rat Fatty acid desaturase 2
    Monoclonal Antibody for Rat Fatty acid desaturase 2
    Monoclonal Antibody for Rat Fatty acid desaturase 2
    Protein for Rat Fatty acid desaturase 2
    Protein for Rat Fatty acid desaturase 2
    Protein for Rat Fatty acid desaturase 2
    Protein for Rat Fatty acid desaturase 2

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    References
    1. 1.
      "Molecular cloning and functional characterization of rat Delta-6 fatty acid desaturase."
      Aki T. , Shimada Y. , Inagaki K. , Higashimoto H. , Kawamoto S. , Shigeta S. , Ono K. , Suzuki O.
      Biochem. Biophys. Res. Commun.255:575-579(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
      strain: Sprague-Dawley.
      tissue: Liver.
    2. 2.
      "Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis."
      Gregory M.K. , Gibson R.A. , Cook-Johnson R.J. , Cleland L.G. , James M.J.
      PLoS ONE6:E29662-E29662(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
      strain: Dark agouti.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    4. 4.
      "Hormonal modulation of delta-6 and delta-5 desaturases: case of diabetes."
      Brenner R.R.
      Prostaglandins Leukot. Essent. Fatty Acids68:151-162(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    5. 5.
      "The desaturation step in the animal biosynthesis of polyunsaturated fatty acids."
      Brenner R.R.
      Lipids6:567-575(1971) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat delta-6-desaturase activity."
      Guillou H. , D'Andrea S. , Rioux V. , Barnouin R. , Dalaine S. , Pedrono F. , Jan S. , Legrand P.
      J. Lipid Res.45:32-40(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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